Mentor
Miranda Sroda - Chemistry and Biochemistry
Advisor
Javier Read de Alaniz - Chemistry and Biochemistry
Cu-Mediated Radical Coupling with Nitroso Compounds
Interns
Cassidy Ballard - Undeclared
Freda Lababidi - Chemical Engineering
Andrew Zhang - Undeclared
Samantha Zhang - Biology
Project Description
We focus on the construction of new carbon-nitrogen bonds, specifically heterocycles containing amino alcohols due to their presence in a variety of biologically active compounds. Current methodologies for nitrogen containing compounds require the use of strong acids and bases, high temperatures, complex procedures, and toxic reagents that are harmful to the environment. We utilize a general, environmentally friendly method that utilizes mild reaction conditions, abundant Cu catalysts and high functional group tolerance. This transformation uses Cu-mediated radical coupling with nitroso compounds towards the synthesis of amino alcohols of various lengths and substitutions in good yields. We continue to extend this approach to access larger rings and a variety of difunctional substrates.
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